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KMID : 0382619840040010223
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Hanyang Journal of Medicine
1984 Volume.4 No. 1 p.223 ~ p.236
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Sister Chromatid Exchanges in Patients with Cervical Cancer
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梁東漢/Bae, Dong Han
金斗相/白龍均/Kim, Doo Sang/Paik, Yong Kyun
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Abstract
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The frequency of sister chromatid echange (SCE) was investigated in cultured lymphocytes form 22 women with cervical cancer together with 22 control women. For scoring SCE, 40 second - and/or third cycle metaphases were analyzed from each subject. The SCE frequencies were found to be 7.75±0.19 and 5.25±0.11 in cancer cases and controls, respectively. The average increase of SCE was about 50% in cancer cases, and the difference is highly significant(P＜0.001). The individual SCE frequency (based on the number of SCE in 40 metaphases) among control subjects was relatively constant compared with cancer patients, and the variance of SCE frequency among controls was significantly smaller than among cancer cases(P＜0.001). Tje SECs in both 6 cases of carcinoma in situ (CIS)and 1 case of cervical dysplasia were found to be significantly more in comparison to controls as well. In comparison to the lymphocytes from healthy controls, the cells responding to PHA-M in cultures from cancer cases showed no cell cycle retardation. The significance of this study in relation to the possibility of using SCE as a preclinical marker for early detection of cervical cancer has been discussed.
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KEYWORD
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